pepteed
Research4 min readUpdated May 2026

MOTS-c: the mitochondrial-derived peptide

MOTS-c is a short peptide notable for being mitochondrial-derived — encoded in mitochondrial rather than nuclear DNA. This overview covers what it is and how it is handled, with no therapeutic or dosing claims.

What it is

MOTS-c is a small peptide that belongs to a class known as mitochondrial-derived peptides. It features in metabolic-research literature, where mitochondrial signalling is an active theme. It is supplied lyophilised.

Why it is studied

MOTS-c is used as a tool compound in preclinical and in-vitro metabolic models. The conclusions belong to those studies; nothing here is a statement about human effects.

Handling notes

  • Reconstitute gently; never shake or vortex.
  • Keep the dry solid sealed, cold and dark.
  • Refrigerate after reconstitution and aliquot for repeated use.

For in-vitro research use only. Not for human or veterinary use.

Mentioned in the catalog
For in-vitro research use only. This guide covers general laboratory handling and is not medical, clinical or dosing advice.